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Assessments of bone cancer-induced pain behavior. (a) Systemic administration of NB001 (30 mg/kg, ip, twice per day for three days) attenuated sarcoma-induced spontaneous lifting compared to saline treated model mice. (b) NB001 treatment improved limb-use on rotarod compared to saline treated model mice. (c) NB001 treatment reversed the mechanical hypersensitivity compared to saline treated model mice. Data are presented as mean ± SE, *p < 0.05 versus model.
