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. 2016 Sep 12;11(9):e0162596. doi: 10.1371/journal.pone.0162596

Fig 1. HDAC inhibition blocks Glyc-alb induced reduction in TEER.

Fig 1

Administration of 100 μg/mL Glyc-alb with and without TSA pretreatment (1 h) to (A) ARPE 19 cells and (B) hfRPE cells showing the resulting TEER at 6 h post treatment compared to the administration of the same concentration of Alb. (C) Concentration-response curve to TSA determined for ARPE19 cells exposed to 100 μg/mL Glyc-alb. Values represent means ± SE of individual measurements normalized to average TEER at 0 h, analyzed by one-way ANOVA. Column numbers represent n for each condition. *p<0.05, **p<0.01, ***p<0.001. Legend: Alb, albumin; Glyc-alb, gAlb, glycated-albumin; TEER, transepithelial electrical resistance; TSA, trichostatin-A.