Fig 6. Effect of L2 on mitochondrial permeability transition pore opening.
(A) Calcium retention capacity (CRC, nmol Ca2+/mg proteins) was studied in sham operated hearts and in hearts subjected to 30 min regional ischemia followed by 20 min reperfusion. (B) Effect of L2 (1 μM) and cyclosporin A (CsA, 1 μM) on CRC when added in vitro to isolated mitochondria that underwent sham or regional ischemia-reperfusion experiments. Data are mean ± SEM. n = 7 per group. $ $, p<0.01 versus sham group, **, p<0.01, ***, p<0.001 versus vehicle IR.