Table 1. Effect of L2 on cardiac contractility in normoxic hearts.
| Normoxic study | n | HR | LVDP | LVEDP | dPmax/dt | dPmin/dt |
|---|---|---|---|---|---|---|
| (bpm) | (mmHg) | (mmHg) | (mmHg/s) | (mmHg/s) | ||
| Control study | 8 | |||||
| Stabilisation | 290 ± 9 | 116 ± 3.6 | 15.44 ± 2 | 3876 ± 42 | -2356 ± 87 | |
| Vehicle | 276 ± 12 | 109 ± 2.3 | 14.23 ± 3 | 3571 ± 76 | -2120 ± 32 | |
| BNP study | 14 | |||||
| Stabilisation | 288 ± 18 | 109 ± 5.6 | 16.28 ± 1 | 4053 ± 63 | -2293 ± 106 | |
| Vehicle | 271 ± 10 | 110 ± 3.7 | 15.84 ± 1 | 3673 ± 211 | -2095 ± 97 | |
| BNP (10 nM) | 277 ± 11 | 102 ± 3.3 | 15.03 ± 1 | 3425 ± 187 | -2332 ± 105 | |
| L2 study | 10 | |||||
| Stabilisation | 272 ± 13 | 112 ± 4 | 15.26 ± 2 | 4132 ± 21 | -242 1 ± 87 | |
| Vehicle | 266 ± 11 | 116 ± 2 | 15.47 ± 2 | 4087 ± 98 | -2582 ± 78 | |
| L2 (100 nM) | 287 ± 17 | 106 ± 5 | 14.74 ± 2 | 3958 ± 110 | -2427 ± 107 | |
| L2 (200 nM) | 291 ± 21 | 104 ± 7 | 15.55 ± 1 | 3993 ± 121 | -2421 ± 92 |
Data are mean ± S.E.M. Heart rate (HR), left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (LVEDP), maximum (dPmax/dt) and minimum (dPmin/dt) rate of rise of ventricular pressure were recorded before and after L2 or BNP perfusion, at stabilisation period and 50 min after drug perfusion. bpm, beat per minute.