Table 3. Effect of L2 on cardiac contractility in hearts subjected to global ischemia-reperfusion experiments.

Global IR study	n	HR		LVEDP		dPmax/dt		dPmin/dt		LVDP
		(bpm)		(mmHg)		(mmHg/s)		(mmHg/s)		(mmHg)
		Stab	R	Stab	R	Stab	R	Stab	R	Stab	R
Control (vehicle)	8	305 ± 8	252 ± 54	18 ± 1	141 ± 5$	3580 ± 128	544 ± 121	-2524 ± 92	-489 ± 66$	112 ± 7	23 ± 2$
BNP (10 nM)	8	310 ± 7	263 ± 53	18 ± 2	125 ± 7$	3580 ± 128	692 ± 120$	-2567 ± 94	-647 ± 101$	113 ± 2	31 ± 4$
L2 (200 nM)	9	305 ± 8	249 ± 21	20 ± 2	117 ± 10$*	3691 ± 94	828 ± 111$*	-2491 ± 62	-735 ± 72$*	113 ± 4	37 ± 3$*

Data are mean ± S.E.M. Heart rate (HR), left ventricular end-diastolic pressure (LVEDP), maximum (dPmax/dt) and minimum (dPmin/dt) rate of rise of ventricular pressure and left ventricular developed pressure (LVDP) were recorded before and after L2 or BNP perfusion, at stabilisation period and at the end of reperfusion. bpm, beat per minute; IR, ischemia-reperfusion; Stab, stabilisation period; R, reperfusion.

*, p<0.05 versus corresponding vehicle value

^$, p<0.05 versus corresponding stabilisation value.