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. 2016 Sep 12;11(9):e0162771. doi: 10.1371/journal.pone.0162771

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© 2016 Tan et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — The schematic illustrations of (A) pCMV-EV71, the CMV promoter-driven EV-A71 infectious clone; (B) pCMV-HH-EV71, the CMV promoter-driven EV-A71 infectious clone with the HH ribozyme before the 5’UTR; (C) pCMV-EV71-HDV, the CMV promoter-driven EV-A71 infectious clone with the HDV ribozyme after the EV-A71 poly(A)₂₅ tail; (D) pCMV-HH-EV71-HDV, the CMV promoter-driven EV-A71 infectious clone with the HH ribozyme upstream of EV-A71 5’UTR and HDV ribozyme downstream of EV-A71 poly(A)₂₅; (E) pT7-EV71, the T7 promoter-driven EV-A71 infectious clone; and (F) wild-type EV-A71. Italicized nucleotides indicate EV-A71 genomic DNA. Arrows indicate transcription start sites. The plaque morphologies of each clone-derived EV-A71 are shown in the right panel.