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. 2015 Oct 15;45(11):1690–1702. doi: 10.1111/cea.12605

Figure 1.

Figure 1

Humoral tolerance is intact in TLR2−/− mice. (a) Schematic of methods for tolerance induction and antibody assessment. Mice were provided with 4 mg/mL OVA in water ad libitum, while control mice were provided with normal water (not depicted). On day 0, all mice were immunized by i.p. injection of OVA‐alum in PBS and then boosted by i.p. injection of OVA in PBS. On day 21, blood and/or faecal samples were harvested. (b) OVA‐specific IgE antibody levels in plasma were compared between tolerized mice treated orally with OVA and control C57BL/6 or TLR2−/− mice following immunization and challenge. Bars represent mean ng/mL IgE ± SEM. (c) OVA‐specific IgA antibody levels in plasma were compared between groups. Bars represent mean A490 ±  SEM. *P < 0.05, **P < 0.01, ***P < 0.001.