Figure 2.
An example figure produced by a neurochemical PET study.
Notes: This diagram was derived from PET imaging of radiotracer 11C-diprenorphine, used to illustrate opioid receptor availability, in patients with OA (n=15) and rheumatoid arthritis (n=2). Regression analysis was performed using the SPM8 software121 to assess the positive relationship between opioid receptor availability and recent McGill pain scores (as a measure of chronic pain over the past week). This diagram illustrates the positive relationship between chronic pain in these patients and opioid receptor binding in the caudate nucleus, nucleus accumbens, and subcallosal area. The highlighted regions indicate regions of significance. Copyright ©2015 Wolters Kluwer. Reproduced with permission from Brown CA, Matthews J, Fairclough M, et al. Striatal opioid receptor availability is related to acute and chronic pain perception in arthritis: does opioid adaptation increase resilience to chronic pain? Pain. 2015;156(11):2267–2275. Promotional and commercial use of the material in print, digital or mobile device format is prohibited without the permission from the publisher Wolters Kluwer Health. Please contact healthpermissions@wolterskluwer.com for further information.
Abbreviations: PET, positron emission tomography; OA, osteoarthritis.