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. 2016 Sep 8;11:4545–4552. doi: 10.2147/IJN.S104635

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© 2016 Jin et al. This work is published and licensed by Dove Medical Press Limited

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Intravenous injection of Thio-Dox/MPEG-PLA NPs inhibited the growth of breast cancer cells in vivo.

Notes: (A) Tumor development curve. Female mice were subcutaneously transplanted 4T1 cells on day 0. On day 5, the mice were randomized into five groups and intravenously injected with saline (control), free Thio, free Dox, free Thio and Dox, and Thio-Dox/MPEG-PLA NPs twice a week. (B) Representative photographs of tumors in each treated group on day 22. (C) Tumor weight in different groups on day 22. (D) Numbers of lung nodules in different groups. For all graphs, error bars indicate mean ± SD, *P<0.05.

Abbreviations: Thio, thioridazine; Dox, doxorubicin; MPEG-PLA, methoxy poly(ethylene glycol)-poly(l-lactic acid); NP, nanoparticle; PEG-PLA, poly(l-lactic acid)-poly(ethylene glycol).

Intravenous injection of Thio-Dox/MPEG-PLA NPs inhibited the growth of breast cancer cells in vivo.

Notes: (A) Tumor development curve. Female mice were subcutaneously transplanted 4T1 cells on day 0. On day 5, the mice were randomized into five groups and intravenously injected with saline (control), free Thio, free Dox, free Thio and Dox, and Thio-Dox/MPEG-PLA NPs twice a week. (B) Representative photographs of tumors in each treated group on day 22. (C) Tumor weight in different groups on day 22. (D) Numbers of lung nodules in different groups. For all graphs, error bars indicate mean ± SD, *P<0.05.

Abbreviations: Thio, thioridazine; Dox, doxorubicin; MPEG-PLA, methoxy poly(ethylene glycol)-poly(l-lactic acid); NP, nanoparticle; PEG-PLA, poly(l-lactic acid)-poly(ethylene glycol).