Table 3.
Multivariable-Adjusted HRs of Cardiovascular Events According to Meeting the National Exercise Guidelines for Patients With Cancer (ie, < 9 v ≥ 9 MET-h/wk)
| MET-h/wk | P | ||
|---|---|---|---|
| < 9 MET-h/wk (n = 1,392) | ≥ 9 MET-h/wk (n = 1,581) | ||
| Median MET-h/wk | 1.6 | 23.4 | |
| Cardiovascular events* | |||
| No. of events | 476 | 386 | |
| Age-adjusted HR (95% CI) | Ref | 0.71 (0.62 to 0.81) | < .001 |
| Multivariable-adjusted HR (95% CI)† | Ref | 0.77 (0.67 to 0.88) | .002 |
| Coronary artery disease | |||
| No. of events | 118 | 85 | |
| Age-adjusted HR (95% CI) | Ref | 0.65 (0.49 to 0.86) | .003 |
| Multivariable-adjusted HR (95% CI)† | Ref | 0.74 (0.55 to 0.99) | .04 |
| Heart failure | |||
| No. of events | 179 | 128 | |
| Age-adjusted HR (95% CI) | Ref | 0.64 (0.51 to 0.80) | .001 |
| Multivariable-adjusted HR (95% CI)† | Ref | 0.71 (0.56 to 0.90) | .01 |
Abbreviations: HR, hazard ratio; MET, metabolic equivalent task.
*
Cardiovascular events include heart failure, coronary artery disease (nonfatal myocardial infarction), arrhythmia, valve abnormality/replacement, stroke, and cardiovascular death.
†
Adjusted for age at diagnosis (> 50 v ≤ 50 years), race, smoking status, body mass index (continuously), menopausal status, stage, adjuvant therapy, study, and preexisting diabetes and/or peripheral artery disease and/or hyperlipidemia and hypertension.