Overall survival by tumor regression grade (TRG) and lymph node status in patients treated with chemotherapy plus surgery in the Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) trial. Patients were stratified into four groups: ypN0 and TRG 1 or 2 (node-negative responders); ypN1+ TRG 1 or 2 (node-positive responders); ypN0 and TRG 3, 4, or 5 (node-negative nonresponders); and ypN1+ and TRG 3, 4, or 5 (node-positive nonresponders). Differences in overall survival were assessed using the Kaplan-Meier method and compared using the log-rank test. A P value of < .05 was considered significant. HR, hazard ratio.