Table 2.

Novel findings on HLA-G and pregnancy.

Observation	Correlation with outcome of pregnancy	Author
HLA-G+ EVT but not HLA-G− VT have immune activating potential and induce Tregs	—	Tilburgs et al. [13]
dNK acquired HLA-G through interaction with EVT and can be reactivated by cytokine stimulation	—	Tilburgs et al. [46]
High HLA-G levels in placental bed correlated with high expression of KIR2DL4 and LILRB1 on dNK cells	—	Djurisic et al. [47]
Enhancer L on HLA-G gene is controlled by CEBP and GATA that are also essential for placentation	—	Ferreira et al. [48]
sHLA-G is higher in maternal blood at GW20 than at term and higher in maternal blood than in umbilical blood	—	Klitkou et al. [49]
Higher 14 bp alleles in fetus are related to higher sHLA-G in maternal blood at term	—	Dahl et al. [50]
sHLA-G in seminal plasma is related to 14 bp ins/del genotype and can predict the success of ART	Positive correlation with the success of ART	Dahl et al. [51]
Higher frequency of 14 bp ins alleles in HLA-G gene is related to the outcome of pregnancy	Positive correlation with RIF	Lashley et al. [52]
Higher sHLA-G and frequency of KIR2DL4+ NK cells in uterine flushing samples from secondary infertile women than in primary infertile woman	Negative correlation with infertility	Rizzo et al. [53]
SNP in 3′ UTR of HLA-G gene is related to outcome of pregnancy	Positive correlation with high risk of preeclampsia	Quach et al. [54]
SNP in 5′ URR of HLA-G gene is related to outcome of pregnancy	Positive correlation with RSA	Agrawal et al. [55]
Lower sHLA-G and PAPP-A in women with GDM at third trimester	—	Beneventi et al. [56]
Higher sHLA-G in women with preexisting rheumatic disease at third trimester	Positive correlation with the success of pregnancy	Beneventi et al. [57]