Table 3.

Novel findings on HLA-G in autoimmune/inflammatory disease.

Type of disease	Observation	Correlation with clinical outcome	Author
CD	Several polymorphisms and one haplotype of HLA-G gene are more frequent in patients than in controls	Positive correlation with susceptibility	Catamo et al. [58]
RA	Several polymorphisms and two haplotypes of HLA-G gene are more frequent in patients than in controls	Positive correlation with susceptibility	Catamo et al. [59]
RA	Two polymorphisms of HLA-G gene are more frequent in RF+ than in RF− patients	Positive correlation with disease severity	Mariaselvam et al. [60]
RA	Homozygosis of 3142G allele is related to lower sHLA-G levels	Positive correlation with high risk of disease	Veit et al. [61]
RA	Higher sHLA-G levels in patients with chronic disease and higher LILRB1 binding in RF− patients	Negative correlation with disease severity	Veit et al. [62]
SLE	HLA-G 14 bp ins/del polymorphisms are associated with susceptibility	Positive correlation with susceptibility	Zhang et al. [63]
SSc	Lower levels of sHLA-G in patients than in controls	Negative correlation with disease severity	Favoino et al. [64]
CD	Higher levels of sHLA-G in patients than in controls	Positive correlation with susceptibility	Zidi et al. [65]
MS	Higher sHLA-G dimers in MS than in controls and in MRI− than in MRI+	Positive correlation with termination of inflammatory response	Fainardi et al. [66]
MS	14 bp ins in HLA-G gene is related to lower sHLA-G levels	Positive correlation with high risk of disease	Mohammadi et al. [67]
T1D	Lower sHLA-G levels in pancreas are detrimental	Negative correlation with disease severity	de Albuquerque et al. [68]
Psoriasis	14 bp del/del genotype of HLA-G gene is more frequent in patients responding to therapy	Positive correlation with response to treatment	Borghi et al. [69]
Asthma	SNPs in 3′ UTR of HLA-G gene modulate the binding of mIRNAs	Positive correlation with high risk of disease	Naidoo et al. [70]