Table 4.
Novel findings on HLA-G and infectious diseases.
Type of disease | Observation | Correlation with clinical outcome | Author |
---|---|---|---|
Toxoplasmosis | Toxoplasma increased the release of sHLA-G by trophoblast inducing apoptosis of dNK cells | Positive correlation with abnormal pregnancy | Han et al. [71] |
Malaria | Higher sHLA-G levels in cord blood are related to low weight at birth and clinical outcome | Positive correlation with high risk of infection in infancy | Sadissou et al. [72] |
Pseudomonas aeruginosa | P. aeruginosa induced HLA-G expression in monocytes and T cells protecting from immune response | — | Bortolotti et al. [73] |
Pseudomonas aeruginosa | sHLA-G levels are decreased during antibiotic therapy in patients with cystic fibrosis | Negative correlation with inflammation | Rizzo et al. [74] |
Helicobacter pylori | HLA-G expression correlated with milder colonization and milder inflammation | Negative correlation with inflammation | Oliveira Souza et al. [75] |
HCV | Higher levels of sHLA-G and IL-10 in patients nonresponding to therapy with IFN | Negative correlation with response to therapy | Khorrami et al. [44] |
HBV | Patients with 14 bp ins/ins genotype have higher levels of HBV activity and HBV DNA copies | Positive correlation with worse clinical outcome | Laaribi et al. [76] |