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. 2016 Aug 29;2016:4326495. doi: 10.1155/2016/4326495

Table 4.

Novel findings on HLA-G and infectious diseases.

Type of disease Observation Correlation with clinical outcome Author
Toxoplasmosis Toxoplasma increased the release of sHLA-G by trophoblast inducing apoptosis of dNK cells Positive correlation with abnormal pregnancy Han et al. [71]
Malaria Higher sHLA-G levels in cord blood are related to low weight at birth and clinical outcome Positive correlation with high risk of infection in infancy Sadissou et al. [72]
Pseudomonas aeruginosa P. aeruginosa induced HLA-G expression in monocytes and T cells protecting from immune response Bortolotti et al. [73]
Pseudomonas aeruginosa sHLA-G levels are decreased during antibiotic therapy in patients with cystic fibrosis Negative correlation with inflammation Rizzo et al. [74]
Helicobacter pylori HLA-G expression correlated with milder colonization and milder inflammation Negative correlation with inflammation Oliveira Souza et al. [75]
HCV Higher levels of sHLA-G and IL-10 in patients nonresponding to therapy with IFN Negative correlation with response to therapy Khorrami et al. [44]
HBV Patients with 14 bp ins/ins genotype have higher levels of HBV activity and HBV DNA copies Positive correlation with worse clinical outcome Laaribi et al. [76]