. Author manuscript; available in PMC: 2016 Sep 13.

Published in final edited form as: JACC Cardiovasc Imaging. 2015 Jul 22;8(8):873–884. doi: 10.1016/j.jcmg.2015.04.016

Table 2.

Multivariate regression model of the association between DNA damage, gene activation, and apoptosis with dose

Outcome	Multivariate Logistic Regression		Exact Logistic Regression
Outcome	DNA Damage (n=57)	Gene Activation (n=51)	Apoptosis (n=25)
OR (95% CI)	1.8 (1.2–2.6)^* for dose	1.0 (0.99–1.1) for dose 2.8 (1.2 – 6.2)^* for DNA damage¹	1.1 (1.0 – 1.2) for dose 1.9 (1.2 – 5.1)^* for DNA damage¹ 1.6 (1.2 – 2.7)^* for gene activation
R²	0.2	0.16	--
Model Score	13.1^#	8.2^#	16.4
P value	0.003	0.002	<0.0001

χ² for Likelihood Ratio Test;

P<0.01.

Model that replaces dose with DNA damage given DNA damage captures the effects of dose.