Table 3.
Demographics and baseline characteristics by classification (mITT population)
| Parameter | Class I (N = 520) | Class II (N = 790) | Class III (N = 600) |
|---|---|---|---|
| Age, years (mean ± SD) | 40.1 ± 13.6 | 47.8 ± 13.2 | 45.4 ± 14.6 |
| Male | 73.7% | 61.5% | 64.0% |
| White | 55.8% | 71.8% | 61.7% |
| BMI, kg/m2 (mean ± SD) | 24.0 ± 3.3 | 29.9 ± 8.4 | 28.2 ± 8.6 |
| Disease condition | |||
| Cellulitis/Erysipelas | 35.4% | 39.2% | 46.8% |
| Major cutaneous abscess | 31.7% | 30.3% | 30.2% |
| Wound infection | 32.9% | 30.5% | 23.0% |
| Lesion size, cm2 (mean ± SD) | 325.7 ± 317.8 | 418.0 ± 471.1 | 466.7 ± 479.1 |
| Days from infection onset to treatment start | 4.3 ± 2.1 | 4.4 ± 2.9 | 4.4 ± 2.4 |
| Meeting SIRS criteria | 0.0% | 0.0% | 55.5% |
| Confirmed MRSA | 24.0% | 17.8% | 20.0% |
| Medical history | |||
| Diabetes mellitus | 0.0% | 20.0% | 18.3% |
| Intravenous drug use | 23.3% | 38.7% | 20.5% |
| Hepatitis/other hepatic condition | 0.0% | 37.6% | 14.3% |
| Renal insufficiency | 0.2% | 1.6% | 2.8% |
SIRS was defined as two or more of the following criteria: Temperature >38 °C, pulse >90 bpm, respiratory rate >20 breaths per minute, white blood cell count >12,000/mm3, or <4000 or >10% bandemia
BMI body mass index, mITT modified intent-to-treat, MRSA methicillin-resistant Staphylococcus aureus, SD standard deviation, SIRS systemic inflammatory response syndrome