Table 2.
Hemodynamic, oxygenation and metabolic variables on admission
| Hemodynamic parameters | All patients (n = 40) | Survivors day 90 (n = 23) | Non-survivors day 90 (n = 17) | p |
|---|---|---|---|---|
| SAP (mmHg) | 114 (98–128) | 121 (106–156) | 114 (97–125) | 0.15 |
| DAP (mmHg) | 72 (57–81) | 76 (62–93) | 72 (50–83) | 0.06 |
| MAP (mmHg) | 80 (63–93) | 85 (75–116) | 75 (60–93) | 0.05 |
| CVP (mmHg) | 9 (7–12) | 10 (9–11) | 9 (7–11) | 0.92 |
| UO (mL/kg/h) | 0.6 (0.3–1.8) | 0.9 (0.3–2.4) | 0.4 (0.2–1.8) | 0.68 |
| HR (beats/min) | 98 (87–112) | 94 (87–105) | 112 (73–126) | 0.91 |
| CI (L/min/m2) | 2.5 (1.9–3.0) | 2.9 (2.5–3.4) | 2.0 (1.5–2.4) | 0.04 |
| SV (mL/beat) | 26 (22–35) | 37 (27–43) | 22 (20–25) | 0.001 |
| SVRI (dynes s/cm5/m2) | 2414 (1932–2881) | 2385 (1685–3346) | 2548 (2264–3918) | 0.97 |
| ScvO2 (%) | 80 (74–87) | 74 (65–76) | 84 (78–90) | 0.61 |
| DO2I (mL/min/m2) | 485 (302–580) | 537 (381–686) | 437 (247–487) | 0.001 |
| PCO2 gap (mmHg) | 7 (4–11) | 7 (5–11) | 7 (4–11) | 0.51 |
| Base deficit (mmol/L) | −3.7 (−7.7 to −0.4) | −3.5 (−5 to 0.5) | −4.5 (−8 to 2) | 0.18 |
| Lactate (mmol/L) | 3.8 (1.5–5.3) | 3.1 (1.4–3.8) | 4 (2.6–4.9) | 0.025 |
| Number of hemodynamic targets reached at the 6th h after admission, n (%)a | 0.007 | |||
| 1 | 13 (32.5 %) | 3 (13 %) | 10 (59 %) | |
| 2 | 12 (30 %) | 7 (30 %) | 5 (29 %) | |
| 3 | 15 (37.5 %) | 12 (52 %) | 3 (17 %) | |
Data are median (interquartile range 25th–75th percentile), or n (%)
SAP systolic arterial pressure, DAP diastolic arterial pressure, MAP mean arterial pressure, CVP central venous pressure, UO urine output, HR heart rate, CI cardiac index, SV stroke volume, SVRI systemic vascular resistance index, ScvO 2 central venous oxygen saturation, DO 2 I oxygen delivery index, PCO 2 gap central venous–arterial PCO2 difference
aHemodynamic targets: MAP ≥65 mmHg, UO ≥0.5 mL/kg/h and CI ≥2.5 L/min/m2