Table 2.
Oyama et al., 2007 | Liang et al., 2010 | Noseda et al., 2015 | |
---|---|---|---|
Injury model | Cryoinjury | Coronary artery ligation | Coronary artery ligation |
Recipient | Adult male Wistar rats | Adult female C57Bl/6 mice | Adult female C57Bl/6 mice |
Donor | Neonatal GFP-transgenic, syngeneic rats | Adult female C57Bl/6 mice | Adult male C57Bl/6 mice |
Transplanted cells | 300,000 cSPCs | 150,000 cSPCs labeled with fluorescent dye | 250,000 cSPC clones labeled with lentiviral mOrange |
Administration route | Tail-vein injection | Intracardiac injection into border zone | Intracardiac injection into border zone |
Functional outcomes | Not assessed | Not assessed | ↓ Infarct size |
↓ Remodeling | |||
↑ Ejection fraction |
Three different approaches have used cSPC transplantation to assess the regenerative ability of cSPCs.