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. 2016 Sep 13;7:1404. doi: 10.3389/fmicb.2016.01404

Table 1.

Lpp of S. aureus USA300.

No Locus tag Function/Annotation PFAM SP (aa) Lipobox Mass (KDa) Disseminationa References
Fe transport
01 SAUSA300_1978 Ferric hydroxamate receptor/FhuD1 Peripla_BP_2 17 LTA C 34 15* Sebulsky and Heinrichs, 2001; Sebulsky et al., 2004
02 SAUSA300_2235 Fe ABC transporter/FhuD2 Peripla_BP_2, ABC2_membrane_3 17 LAA C 34 16 Sebulsky and Heinrichs, 2001; Sebulsky et al., 2004; Mariotti et al., 2013
03 SAUSA300_0721 Transferrin receptor/SstD Peripla_BP_2 18 LAA C 38 14 Morrissey et al., 2000
04 SAUSA300_0117 Fe ABC transporter/SirA Peripla_BP_2 20 LAG C 37 10 Heinrichs et al., 1999
05 SAUSA300_1032 Fe ABC transporter/IsdE Peripla_BP_2 19 LTS C 32 10 Mazmanian et al., 2002, 2003; Grigg et al., 2007
06 SAUSA300_0344 FepA, Fe-binding protein, part of fepABC and tat-AC cluster Peptidase_M75 17 IAA C 32 10 Biswas et al., 2009
07 SAUSA300_2136 Fe ABC transporter Peripla_BP_2 21 VAA C 36 14
08 SAUSA300_0219 Iron Binding Protein SBP_bac_1, 6, 8, 11 17 LSA C 36 4*
Other cation transport
09 SAUSA300_0618 Manganese-binding protein MntC (SitC) ZnuA, Nit_Regul_Hom 17 VAA C 34 19 Cockayne et al., 1998; Müller et al., 2010; Diep et al., 2014
10 SAUSA300_2351 Zinc-binding, adcA-like ZnuA, ZinT 20 LAA C 57 10
11 SAUSA300_2411 Cobalt and nickel transporter Cnt (Opp1A) SBP_bac_5 20 LTG C 59 10 Remy et al., 2013
12 SAUSA300_0231 Nickel ABC transporter SBP_bac_5 18 LSG C 55 10*
13 SAUSA300_0203 Nickel-Peptide/transporter substrate-binding protein SBP_bac_5 18 LSG C 66 +
14 SAUSA300_2230 Molybdenum ABC transporter (ModA) SBP_bac_11, 1, PBP_like_2 19 LAG C 29 15 Neubauer et al., 1999
Anion transport
15 SAUSA300_1283 Phosphate ABC transporter PBP_like_2, PBP_like 20 LGA C 36 15
16 SAUSA300_0145 Phosphonate ABC transporter Phosphonate-bd, SBP_bac_3 20 AAA C 35 10
17 SAUSA300_0175 Nitrate ABC transporter substrate-binding protein NMT1_2, 17 ITG C 36 4
AA and Peptide transport
18 SAUSA300_2391 Glycine betaine /carnitine/ choline ABC transporter (OpuCc) OpuAC 20 LSG C 37 19
19 SAUSA300_2359 Amino acid ABC transporter SBP_bac_3 17 LAA C 13 12
20 SAUSA300_0073 Peptide ABC transporter SBP_bac_5 19 LAG C 57 11
21 SAUSA300_0891 Oligopeptide ABC transporter (Opp3A) SBP_bac_5 20 LSG C 61 11 Hiron et al., 2007
22 SAUSA300_0892 Oligopeptide ABC transporter (Opp4A) SBP_bac_5 20 LSA C 63 5 Hiron et al., 2007
23 SAUSA300_0437 NLPA/ D-Methionine binding (GmpC) Lipoprotein_9 (NLPA) 17 LAA C 31 9 Williams et al., 2004
24 SAUSA300_0798 D-Methionine ABC transporter OpuAC, Lipoprotein_9 19 LAA C 30 15
Sugar transport
25 SAUSA300_0209 Maltose ABC transporter SBP_bac_1, 8 20 VTA C 47 6
Miscellaneous functions
Biosynthesis
26 SAUSA300_1884 CamS sex pheromone biosynthesis CamS 17 LAA C 44 14
Respiration
27 SAUSA300_0963 Quinol oxidase, subunit II (QoxA) COX2 19 LSG C 41 21
28 SAUSA300_0693 Electron transfer domain/SaeP CfAFP, DM13 20 LGA C 16 22 Makgotlho et al., 2013
Chaperone-Foldases
29 SAUSA300_1790 Foldase protein PrsA Rotamase, 20 LGA C 36 15 Heikkinen et al., 2009; Jousselin et al., 2012
30 SAUSA300_2354 Thioredoxin/Protein disulfide-isomerase Thioredoxin_2, 4, 5 18 LTA C 22 15*
Protein translocation
31 SAUSA300_2046 YidC (OxaA)–essential protein OATP, 60KD_IMP 19 LAG C 32 25
Phage and plasmid encoded Lpp
32 SAUSA300_1436 PhiSLT ORF144-like DUF1510, Zip, Presenilin 17 LTA C 16 2*
33 pUSA300_HOUMR0011 Membrane bound penicillinase BlaZ 16 LSA C 31 11 Nielsen and Lampen, 1982b
Lpl cluster
34 SAUSA300_0410 Lpl-1 νSaα specific DUF576 32 IAG C 30 + Nguyen et al., 2015b
35 SAUSA300_0411 Lpl-2 νSaα specific DUF576 22 IIG C 30 + Nguyen et al., 2015b
36 SAUSA300_0413 Lpl-3 νSaα specific DUF576 23 IIG C 30 + Nguyen et al., 2015b
37 SAUSA300_0414 Lpl-4 νSaα specific DUF576 22 VTS C 28 + Nguyen et al., 2015b
38 SAUSA300_0415 Lpl-5 νSaα specific DUF576 22 IMG C 29 + Nguyen et al., 2015b
39 SAUSA300_0416 Lpl-6 νSaα specific DUF576 20 MAG C 29 + Nguyen et al., 2015b
40 SAUSA300_0417 Lpl-7 νSaα specific DUF576 23 IVG C 30 + Nguyen et al., 2015b
41 SAUSA300_0418 Lpl-8 νSaα specific DUF576 22 VTS C 29 + Nguyen et al., 2015b
42 SAUSA300_0419 Lpl-9 νSaα specific DUF576 22 IGG C 30 + Nguyen et al., 2015b
43 SAUSA300_2429 Tandem lpp DUF576 22 IGG C 16 3*
44 SAUSA300_2430 Tandem lpp DUF576 23 IGA C 29 +
45 SAUSA300_0100 Tandem lpp/Conserved staphylococcal antigen 1A (Csa1A) DUF576 24 TAG C 28 + Schluepen et al., 2013
46 SAUSA300_0101 Tandem lpp DUF576 24 TAG C 28 +
47 SAUSA300_0102 Tandem lpp DUF576 24 TAG C 28 +
48 SAUSA300_0103 Tandem lpp DUF576 23 TAG C 28 +
Unknown function
49 SAUSA300_0079 Unknown function DUF1541 18 LSA C 20 17
50 SAUSA300_0372 Unknown function PepSY 18 LTA C 21 17*
51 SAUSA300_0377 Unknown function DUF1748 19 LTG C 23 14
52 SAUSA300_1492 Unknown function 16 LAG C 13 15*
53 SAUSA300_0992 Cell-wall binding lipoprotein YkyA, EzrA 19 LAG C 23 13*
54 SAUSA300_2403 Unknown function DUF1307 20 LSA C 17 12*
55 SAUSA300_0724 Unknown function IncA, TarH 19 ISA C 32 12
56 SAUSA300_2315 Unknown function PA26, IncA, CLN3 17 LAA C 23 11*
57 SAUSA300_2614 Unknown function DUF_1980 20 LYS C 42 6
58 SAUSA300_0663 Unknown function PA26, IncA 17 LTG C 15 5
59 SAUSA300_1106 Unknown function FAM176 18 VAG C 35 5*
60 SAUSA300_0303 Unknown function DUF4467 17 LAG C 14 5*
61 SAUSA300_1478 Unknown function DUF4467 17 LSA C 13 3*
62 SAUSA300_1376 Unknown function DUF1672 17 LSG C 34 2*
63 SAUSA300_1379 Unknown function DUF1672 17 LSG C 34 2*
64 SAUSA300_1440 Unknown function DUF1672 17 LGG C 34 2*
65 SAUSA300_1742 Unknown function 18 LTA C 23 2*
66 SAUSA300_1741 Unknown function ETRAMP, Myco_19_kDa 18 LTA C 6 +
67 SAUSA300_0769 Unknown function DUF5067 17 LGA C 27 +
a

The number indicates the number of staphylococcal species in which the corresponding homologues gene/protein (more than 40% identity over the whole protein length) is present.

+S. aureus specific gene.

*

Staphylococcal specific gene.

The corresponding gene has been compared in 34 staphylococcal species and other genera in which genome sequence has been available. Abbreviations: 60KD_IMP, 60Kd inner membrane protein; ABC2_membrane_3, ABC-2 family transporter protein; CamS, CamS sex pheromone cAM373 precursor; CfAFP, Choristoneura fumiferana antifreeze protein (CfAFP); CLN3, CLN3 protein; DM13, Electron transfer DM13; COX2, Cytochrome C oxidase subunit II; DUF, Domain Unknown Function; ETRAMP, Malarial early transcribed membrane protein (ETRAMP); EzrA, Septation ring formation regulator, IncA, IncA protein; Myco_19_kDa, Mycobacterium 19 kDa lipoprotein antigen; NMT1_2, NMT1-like family; Nit_Regul_Hom, Uncharacterized protein, homolog of nitrogen regulatory protein PII; OATP, Organic Anion Transporter Polypeptide (OATP) family; OpuAC, Substrate binding domain of ABC-type glycine betaine transport system; PA26, PA26 p53-induced protein (sestrin); PBP_like_2, PBP superfamily domain; PepSY, Peptidase propeptide and YPEB domain; Peripla_BP_2, Periplasmic binding protein; Pfam, Protein Families; Phosphonate-bd, ABC transporter, phosphonate, periplasmic substrate-binding protein; Rotamase, PPIC-type PPIASE domain; SBP_bac, Bacterial extracellular solute-binding protein; SP, Signal Peptide; TarH, Tar ligand binding domain homolog; YkyA, Putative cell-wall binding lipoprotein; ZnuA, Zinc-uptake complex component A periplasmic; ZinT, (YodA) periplasmic lipocalin-like zinc-recruitment; Zip, ZIP Zinc transporter.