Table 5.
Mean change from baseline in creatinine clearance, serum creatinine, and serum phosphorus (all patients with available data)
| Baseline | Month 12 | Month 24 | Month 36 | |
|---|---|---|---|---|
| Creatinine clearance (n) Median (range) change from baseline (mL/min) | ||||
| Overall | 352 | 245 −1.78 (−65.80, 44.81) |
213 −1.11 −82.13, 50.65) |
200 −3.26 (−69.76, 48.50) |
| Treatment-naive | 137 | 88 −2.45 (−42.83, 44.81) |
76 2.42 (−39.79, 50.65) |
72 −6.58 (−61.56, 46.34) |
| Treatment-experienced | 215 | 157 −1.48 (−65.80, 35.45) |
137 −1.37 (−82.13, 49.94) |
128 −1.85 (−69.76, 48.50) |
| Serum creatinine (n) Median (range) change from baseline (µmol/L) | ||||
| Overall | 257 | 249 0.00 (−44.00, 81.20) |
217 −0.8 (−44.00, 56.90) |
204 0.74 (−37.00, 45.00) |
| Treatment-naive | 110 | 92 0.00 (−23.00, 28.90) |
80 0.22 (−27.80, 38.00) |
76 3.00 (−34.00, 619.20) |
| Treatment-experienced | 151 | 159 −0.44 (−44.00, 419.00) |
138 −2.00 (−44.00, 56.90) |
130 −0.75 (−145.90, 42.00) |
| Serum phosphorus (n) Median (range) (mg/dL) | ||||
| Overall | 157 1.01 (0.51, 1.56) |
185 1.02 (0.56, 1.60) |
150 0.98 (0.57,3.00) |
136 1.00 (0.51, 1.82) |