Table 7.
Proportion of patients with a decline in estimated glomerular filtration rate of ≥20 % compared with baseline, ≥30 % compared with baseline and eGFR values <60 mL/min/1.73 m2
| Proportion of patients with | Treatment group | ||||
|---|---|---|---|---|---|
| Overall N = 440 |
Treatment-naïve n = 182 |
Treatment-experienced n = 258 |
Prior ADV n = 179 |
No Prior ADV n = 261 |
|
| eGFR decline ≥ 20 % versus baseline, n (%) |
65 (15) | 22 (12) | 43 (17) | 31 (17) | 34 (13) |
| P = 0.220 | P = 0.221 | ||||
| eGFR decline ≥30 % versus baseline, n (%) |
26 (6) | 8 (4) | 18 (7) | 10 (6) | 16 (6) |
| P = 0.308 | P = 1.00 | ||||
| eGFR <60 mL/min/1.73 m2, n (%) |
48 (11) | 3 (2) | 45 (17) | 35 (20) | 13 (5) |
| P < 0.001 | P < 0.001 | ||||
ADV adefovir, eGFR estimated glomerular filtration rate
P values calculated using Fisher’s exact test (two-sided)