Table 1.

Review objective and PICO elements

Review objective	To review the economic impact of PT-guided therapies; highlight the differences and methodological characteristics of the included studies
Populations	Studies of participants who received a pharmacogenetic therapy; studies were not restricted to specific indications
Interventions/comparison	Studies that compare the application of targeted agents with prior genetic testing to those without prior genetic testing. The review is not limited to specific comparators
Outcomes	ICER (e.g., cost per QALY, cost per LYG, cost per avoided HSR/ADR)

PICO population–intervention–comparator–outcome, QALY quality-adjusted life year, LYG life-years gained, HSR hypersensitivity reaction, ADR adverse drug reaction