Figure 2.
PBPK model predictions of BaP in the perfusate of SD rat lungs that are isolated, ventilated, and perfused (Ewing et al., 2006) following inhalation of BaP-coated silica particles (3.5 μm MMAD, 1.73 σ). Two-second puffs at 1.69 ml/breath, 75 breaths per minute were administered endotracheally at three concentrations (lines are for concentrations of 0.065 (dashed line, circles), 1.73 (dotted line, triangles) and 554.7 (solid lines, diamonds) mg BaP/m3). Symbols indicate mean values of n = 3 rats.