Table 2. BaP-carrier particle characteristics and exposures for studies used in PBPK model parameterization.
| Source | Species | Particle type (diameter, GSD a ) | Particle concentration (mg/m3) | BaP concentration (mg/m3) | Exposure duration | Fraction or mass of BaP deposited in Lung | Dose metric endpoints |
|---|---|---|---|---|---|---|---|
| Ewing et al., (2006) | SD Rat | Silica (3.5 b , 1.73) | 680–3000 | 0.07–555 | 2 min | 2.2–8400 μg | BaP in lung perfusate |
| Sun et al., (1982) | F-344 Rat | 67Ga2O3 (0.1 c , 1.6) | 3.5 | 0.6 | 30 min | 22.4% | Lung, liver, blood, GI tract radioactivity |
| Sun et al., (1984) | F-344 Rat | Diesel soot (0.13 c , 1.5) | 3.9 | 0.006 | 30 min | 16% | Lung, liver, blood, GI tract radioactivity |
| Lafontaine et al., (2004) | Humans | Not reported | Not Reported | 0.00002–0.0015 | 4-10 h | 19.8% d | Urinary 3-OH BaP |
a
Geometric standard deviation.
b
MMAD: Mass median aerodynamic diameter (μm).
c
MMD: Mean aerodynamic diameter (μm).
d
Estimated with MPPD software ver. 2.11 using a particle size of 0.3 μm (MMAD) and GSD of 3.0 (treated as a polydisperse particle distribution by MPPD). All others were supplied in the published papers.