Table 11. Incidence of treatment-related microscopic findings – day 26.
| Examined organs/microscopic findings | Mixed chlorinated DPP isomers | Fine Pigment Red 254 | Coarse Pigment Red 254 | Fine meta-chloro DPPa | Coarse meta-chloro DPP | Fine Pigment Red 101 | Coarse Pigment Red 101 | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Concentration (mg/m³) | 30 | 30 | 30 | 3 | 10 | 30 | 3 | 10 | 30 | 10 | 30 | 30 |
| No. of animals/test group | 3 | 3 | 3 | 3 | 3 | 2 | 3 | 3 | 3 | 3 | 3 | 3 |
| Lung | ||||||||||||
| Pigment-laden macrophages, decreased (compared to day 5) | 3 | 3 | 3 | 3 | 3 | 2 | 0 | 0 | 3 | 3 | 3 | 3 |
| Pigment-laden macrophages and/ or particles in BALT | 3 | 3 | 3 | 3 | 3 | 1 | 0 | 0 | 3 | 3 | 3 | 3 |
| Mediastinal/tracheobronchial lymph nodes | ||||||||||||
| Pigment-laden macrophages/pigment particles | 3 | 3 | 2 | 0 | 3 | 2 | 0 | 3 | 3 | 2 | 3 | 2 |
| Lymphoreticular hyperplasia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| Nasal cavity | a | a | a | a | a | a | a | a | a | |||
| Pigment particles, luminal | 0 | 1 | 0 | |||||||||
| Larynx | a | a | a | a | a | a | ||||||
| Pigment-laden macrophages/pigment particles, luminal | 0 | 0 | 0 | 0 | 2 | 0 | ||||||
| Trachea | a | a | a | a | a | a | a | a | a | |||
| Pigment-laden macrophages/pigment particles, luminal | 0 | 0 | 0 | |||||||||
a
Not examined.