Multivariable-adjusted* association of periodic limb movements index and clinically significant cognitive impairment as measured by the Trail Making Test – Part B (completion time increased by 58 sec), odds ratio, and 95% confidence interval (CI) (n = 2,343). *Models adjusted by age, site, race (white vs. nonwhite), education level, physical activity level, history of diabetes mellitus, history of hypertension, history of coronary heart disease.