Treatment effect on the total activity on days 2, 8, 15 and 22. Total activity was measured for 30 min, half hour after treatment on days 2, 8, 15, 22. Data are presented as mean ± SD, with 8 rats per group (one-way ANOVA followed by Tukey test). Total degree of freedom = 39. p < 0.05: no symbol, * p < 0.05, ** p < 0.01, *** p < 0.001.