Table 2.
Cardiac weights, LV fibrosis, and serum levels of cTnT
| C-NNa | C-HNa | ACRF-NNa | ACRF-HNa | ANOVA effects, p value |
|||
|---|---|---|---|---|---|---|---|
| (n = 9) | (n = 10) | (n = 10) | (n = 8) | adenine | NaCl intake | interaction | |
| Body weight, g | 369±31 | 343±23 | 387±27 | 346±32 | n. s. | <0.01 | n.s. |
| LVW, g/kg BW | 2.33±0.24 | 2.25±0.12 | 3.24±0.35 | 3.54±0.40 | <0.001 | n.s. | <0.05 |
| RVW, g/kg BW | 0.54±0.09 | 0.56±0.09 | 0.66±0.08 | 0.71±0.13 | <0.001 | n.s. | n.s. |
| LV fibrosis, % | 2.9±0.9 | 2.5±0.6 | 3.4±1.4 | 10 7±5.1 | <0.001 | <0.001 | <0.001 |
| LV PV fibrosis, µm2/µm | 76±15 | 50±7 | 83±12 | 90±11 | <0.001 | <0.05 | <0.001 |
| Serum cTnT, ng/l | 30±17 | 16±12 | 172±184 | 740±342 | <0.001 | <0.001 | <0.001 |
Data are derived from acute experiments performed approximately 10–12 weeks after the beginning of the study (see Methods). All animals received chow with a normal (0.6%) NaCl content from the beginning of the study until 2 weeks prior to the acute experiments, when the animals were randomized to either remain on the same diet (NNa) or be switched to high-NaCl (4%) chow (HNa). Values are means ± SD. Main effects and between-factor interaction from two-factorial ANOVA are presented. LVW = LV weight; RVW = right ventricular weight; BW = body weight; PV = perivascular; n. s. = not significant.