Table 3. Comparison of the performance of different methods in the analysis of 48 ligand-bound/unbound structures.

Method	Bound Protein		Unbound Protein
	Top 1 (%)	Top 3 (%)	Top 1 (%)	Top 3 (%)
MF-PLB	85	96	83	92
PLB	81	94	75	90
MPK21	85	96	80	94
MPK12	83	96	75	90
Q-SiteFinder2	75	90	52	75
LISE3	92	96	81	92
Ligsite-csc4	79	—	71	—
Ligsite-cs4	81	92	71	85
PASS4	63	81	60	71
SURFNET4	54	78	52	75
SiteHound	71	90	63	81

¹Data from²⁰.

²Data from²¹.

³Data from¹⁹.

⁴Data from¹⁵.