Table 2.
Predictors of sustained virologic response among those treated with boceprevir- or telaprevir-based regimens
| Odds ratio univariable | 95% CI | Odds ratio multivariable | 95% CI | |
|---|---|---|---|---|
| Age, for each 10 year increase | 0.85 | 0.76, 0.95 | 0.94 | 0.83, 1.07 |
| Sex, male vs female | 1.04 | 0.7, 1.56 | 1.03 | 0.66, 1.61 |
| Race/ethnicity | ||||
| White | 1 | |||
| Black | 0.67 | 0.56, 0.8 | 0.72 | 0.59, 0.87 |
| Hispanic | 1.24 | 0.78, 1.96 | 1.3 | 0.78, 2.15 |
| Other | 1.13 | 0.89, 1.43 | 1.19 | 0.92, 1.54 |
| Body mass index, each one unit | 0.99 | 0.97, 1.004 | 0.99 | 0.96, 1.01 |
| increase in kg/m2 | ||||
| Body mass index | ||||
| <30 vs ≥30 kg/m2 | 1.1 | 0.94, 1.29 | 1.05 | 0.79, 1.39 |
| Cirrhosis | 0.54 | 0.45, 0.65 | 0.42 | 0.34, 0.53 |
| Treatment experienced Ms treatment | 0.66 | 0.56, 0.78 | 0.76 | 0.63, 0.91 |
| naive | ||||
| Completed full course of treatment | 2.63 | 2.24, 3.08 | 2.52 | 2.12, 3.00 |
| HCV RNA, log IU/mL | 0.91 | 0.88, 0.94 | 0.91 | 0.87, 0.94 |
| Baseline alanine aminotransferase | 1.002 | 1.001, 1.004 | 1.004 | 1.002, 1.01 |
| level, U/L | ||||
| Presence of diabetes | 0.78 | 0.64, 0.95 | 0.89 | 0.72, 1.11 |
| ESA use | 0.93 | 0.78, 1.1 | 0.85 | 0.70, 1.03 |
| Use of statins | 1.18 | 0.92, 1.5 | 1.29 | 0.99, 1.70 |
| Anaemia at baseline | 0.56 | 0.41, 0.78 | 0.75 | 0.52, 1.07 |
| Anaemia on treatment | 2.04 | 1.49, 2.78 | 1.95 | 1.34, 2.83 |
| Genotype (1a is the comparator group) | ||||
| 1b | 1 | 0.81, 1.24 | 1.06 | 0.85, 1.33 |
| Not specified | 1.1 | 0.85, 1.41 | 1.14 | 0.87, 1.49 |
| BOC vs TPV (TPV is the | 1.04 | 0.84, 1.29 | 0.82 | 0.65, 1.05 |
| comparator group) |
BOC, boceprevir-containing regimen; TPV, telaprevir-containing regimen; ESA, erythropoiesis-stimulating agent.