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(A) Crystal structure of SMYD2 bound to p53 peptide (PDB code 3TG5). (B) Chemical structures of SMYD2 inhibitors. (C) Overlay of binding modes of SMYD2 inhibitors LLY-507 (4WUY) and A-893 (4YND) and p53 peptide. The weaker compound AZ505 binds to the same site but has been omitted for clarity. S-adenosyl methionine position included for reference.
SAM: S-adenosyl methionine.
