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. 2016 Sep 13;5:27. doi: 10.1186/s40164-016-0056-z

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Induction of apoptosis by SFN as determined by changes in PARP cleavage, appearance of p-H2AX, decreases in pro-caspase 2 and pro-caspase 3. Western blot analysis revealed down regulation of PARP expression as evidenced by appearance of the 89-kDa PARP cleavage product, induction of p-H2AX, and down-regulation of both pro-caspase 2 and pro-caspase 3 in ≥ 10 μM, 48 h SFN treated cells