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Intracerebroventricular deferoxamine dose-tolerance chart
| ICV dose | Total mice tested | Tolerance |
|---|---|---|
| 0.8 mg/kg (~0.02 mg per mouse) | 3 | Well tolerated |
| 8 mg/kga (~0.2 mg per mouse) | 3 | Well tolerated |
| 80 mg/kg (~2 mg per mouse) | 2 | Immediately died |
Wild-type mice were injected with a one-time intracerebroventricular (ICV) dose of deferoxamine diluted in normal saline, to test how well each dose would be tolerated
aThe highest dose tolerated was chosen for all experimental procedures
