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. 2016 Sep 13;16(1):730. doi: 10.1186/s12885-016-2770-7

Table 3.

Heterogeneity of c-MYC and ß-catenin with respect to tumor location in advanced CRC (cohort 2)

cMYC IHC		Distant metastasis		LN metastasis
cMYC IHC		Negative	Positive	Negative	Positive
Primary	Negative	52 (29.5 %)	22 (12.5 %)	23 (20.7 %)	21 (18.9 %)
	Positive	58 (33.0 %)	44 (25.0 %)	14 (12.6 %)	53 (47.7 %)
cMYC mRNA ISH		Distant metastasis		LN metastasis
cMYC mRNA ISH		Negative	Positive	Negative	Positive
Primary	Negative	19 (10.8 %)	20 (11.4 %)	8 (7.2 %)	17 (15.3 %)
Primary	Positive	25 (14.2 %)	112 (63.6 %)	17 (15.3 %)	69 (62.2 %)
ß-catenin IHC		Distant metastasis		LN metastasis
ß-catenin IHC		Negative	Positive	Negative	Positive
Primary	Negative	55 (31.3 %)	14 (8.0 %)	30 (27.0 %)	13 (11.7 %)
Primary	Positive	37 (21.0 %)	70 (39.8 %)	16 (14.4 %)	52 (46.8 %)

Abbreviations: IHC immunohistochemistry, ISH in-situ hybridization