Table 4.
Multivariate Cox proportional hazard models for the predictors of overall survival
| Factors | Univariate survival analysis | Multivariate survival analysis | ||
|---|---|---|---|---|
| HR (95 % CI) | P value | HR (95 % CI) | P value | |
| Cohort 1 | ||||
| co-expression of c-MYC and ß-catenin | 0.482 (0.310–0.749) | 0.012 | 0.629 (0.397–0.996) | 0.048 |
| Age | 1.026 (1.008–1.045) | 0.005 | 1.022 (1.004–1.040) | 0.015 |
| Size | 1.244 (1.059–1.244) | 0.001 | 1.049 (0.946–1.163) | NS (0.362) |
| Histologic grade (high vs. low) | 3.143 (1.904–5.188) | <0.001 | 2.842 (1.608–5.023) | <0.001 |
| Stage (3/4 vs. 1/2) | 6.151 (3.494–10.829) | <0.001 | 2.942 (1.538–5.628) | 0.001 |
| Lymphatic invasion | 3.661 (2.242–5.980) | <0.001 | 1.338 (0.763–2.349) | NS (0.310) |
| Perineural invasion | 3.942 (2.648–5.870) | <0.001 | 2.337 (1.487–3.673) | <0.001 |
| Venous invasion | 3.985 (2.671–5.946) | <0.001 | 2.163 (1.390–3.366) | 0.001 |
| c-MYC mRNA expression | 0.599 (0.403–0.891) | 0.011 | 0.703 (0.464–1.066) | NS (0.097) |
| Age | 1.026 (1.008–1.045) | 0.005 | 1.024 (1.006–1.042) | 0.008 |
| Size | 1.244 (1.059–1.244) | 0.001 | 1.056 (0.953–1.169) | NS (0.297) |
| Histologic grade (high vs. low) | 3.143 (1.904–5.188) | <0.001 | 2.785 (1.562–4.968) | 0.001 |
| Stage (3/4 vs. 1/2) | 6.151 (3.494–10.829) | <0.001 | 3.017 (1.574–5.782) | 0.001 |
| Lymphatic invasion | 3.661 (2.242–5.980) | <0.001 | 1.327 (0.756–2.330) | NS (0.324) |
| Perineural invasion | 3.942 (2.648–5.870) | <0.001 | 2.438 (1.554–3.827) | <0.001 |
| Venous invasion | 3.985 (2.671–5.946) | <0.001 | 2.102 (1.356–3.259) | 0.001 |
| c-MYC protein expression | 0.593 (0.400–0.880) | 0.010 | 0.751 (0.498–1.132) | NS (0.171) |
| Age | 1.026 (1.008–1.045) | 0.005 | 1.023 (1.005–1.041) | 0.012 |
| Size | 1.244 (1.059–1.244) | 0.001 | 1.054 (0.951–1.169) | NS (0.317) |
| Histologic grade (high vs. low) | 3.143 (1.904–5.188) | <0.001 | 2.967 (1.681–5.236) | <0.001 |
| Stage (3/4 vs. 1/2) | 6.151 (3.494–10.829) | <0.001 | 2.959 (1.549–5.653) | 0.001 |
| Lymphatic invasion | 3.661 (2.242–5.980) | <0.001 | 1.344 (0.766–2.356) | NS (0.303) |
| Perineural invasion | 3.942 (2.648–5.870) | <0.001 | 2.388 (1.522–3.746) | <0.001 |
| Venous invasion | 3.985 (2.671–5.946) | <0.001 | 2.105 (1.356–3.269) | 0.001 |
| ß-catenin protein expression | 0.666 (0.449–0.986) | 0.042 | 0.740 (0.497–1.101) | NS (0.138) |
| Age | 1.026 (1.008–1.045) | 0.005 | 1.023 (1.005–1.041) | 0.012 |
| Size | 1.244 (1.059–1.244) | 0.001 | 1.068 (0.966–1.180) | NS (0.197) |
| Histologic grade (high vs. low) | 3.143 (1.904–5.188) | <0.001 | 2.897 (1.645–5.102) | <0.001 |
| Stage (3/4 vs. 1/2) | 6.151 (3.494–10.829) | <0.001 | 3.034 (1.587–5.801) | 0.001 |
| Lymphatic invasion | 3.661 (2.242–5.980) | <0.001 | 1.356 (0.771–2.383) | NS (0.290) |
| Perineural invasion | 3.942 (2.648–5.870) | <0.001 | 2.367 (1.508–3.717) | <0.001 |
| Venous invasion | 3.985 (2.671–5.946) | <0.001 | 2.071 (1.331–3.224) | 0.001 |
| Primary tumor of cohort 2 | ||||
| co-expression of c-MYC and ß-catenin | 0.430 (0.254–0.726) | 0.001 | 0.440 (0.259–0.747) | 0.002 |
| Age | 1.023 (1.001–1.045) | 0.037 | 1.025 (1.004–1.047) | 0.020 |
| Stage (3/4 vs. 1/2) | 7.894 (1.922–32.418) | 0.004 | 5.731 (1.380–23.800) | 0.016 |
| Lymphatic invasion | 2.480 (1.402–4.386) | 0.002 | 1.712 (0.940–3.117) | NS (0.079) |
| Perineural invasion | 2.119 (1.313–3.421) | 0.002 | 1.724 (1.049–2.831) | 0.032 |
P-values are calculated by using χ2-test or Fisher’s exact test
Abbreviations: HR hazard ratio