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. 2016 Sep 13;10(1):91. doi: 10.1186/s12918-016-0335-7

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Comparison of flux rejection between observed and simulated data following model modification. Panels depict a calculated flux magnitude and b the percent of simulations in which the calculated fluxes were found to be non-significant (with asterisks indicating fluxes calculated to be non-significant using observed data). Simulated data was drawn from a modification of the stoichiometric model described in the Methods section (with balances on NADH and NADPH), constrained by 99 % confidence intervals on fluxes observed at 66 hours post inoculation. 100 balanced flux profiles were generated with 100 random generated sets of measurement error applied to each. See Additional file 2 for reaction definitions