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. 2016 Sep 13;35(1):140. doi: 10.1186/s13046-016-0413-0

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Inhibition of IRAK1 attenuates tumor growth in subcutaneous HCC models. a Xenografted tumor of SMMU-7721 cell lines stably transfected with lentivirus-delivering shRNA for IRAK1 (shIRAK2) in nude mice. b The graph shows changes in the volume or weight of tumors. The data are the mean ± SE (n = 4). c The Ki67 staining of Xenografted tumor (X100 and X200). d The graph shows changes in the volumes or weights of tumors. The data are the mean ± SE (n = 4). SMMU-7721 cell lines were implanted subcutaneously in mice and allowed to grow until the tumors reached a size of approximately 150 mm³. Xenografted mice were randomized and injected i.p. with 2.12 mg/kg IRAK1/4 inhibitor 4 times per week. Two weeks later, the average tumor volumes and weights of the IRAK1/4 inhibitor group were analyzed comparing with the control group. Tumor volumes from two groups were analyzed by two-way ANOVA analysis (*p < 0.05). The graph shows individual tumor volume (t-test, *p < 0.05)