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. Author manuscript; available in PMC: 2016 Sep 13.
Published in final edited form as: J Control Release. 2013 Aug 23;172(1):179–189. doi: 10.1016/j.jconrel.2013.08.015

Figure 3. Preparation and characterization of LHH NP.

Figure 3

a) Schematic illustration of LHH NP preparation. Anionic siRNA and HA is mixed with cationic TH and DOTAP/Cholesterol liposome to form the core-shell structure complex. The NP is then PEGylated through post-insertion by heating. b) Particle size and zeta potential characterization by Dynamic Light Scattering and Laser Doppler Velocimetry. c) TEM imaging of LHH NP after uranyl acetate staining. Scale bar: 100 nm.