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NF‐κB/Mitochondria pathway is involved in beta cells apoptosis induced by LIGHT in the presence of IFN‐γ. LIGHT signalling activates NF‐κB‐mediated mitochondrial pathway via the regulation of Bcl‐2 family member's expression, followed with mitochondrial permeabilization, and cytochrome c release, and caspase‐9 activation. Caspase‐9 then activates caspase‐3. The signal from caspase‐3 is transmitted to PARP and then leads to cells apoptosis.
