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. 2016 Sep 13;6:32659. doi: 10.1038/srep32659

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Examples of in vivo CT angiography, RP805 (MMP-targeted) microSPECT, and fused microSPECT and CT transverse images of control (top row) and doxycycline-treated (for 3 months) apoE^−/− mice (bottom row) after 6 months of high fat diet. Arrows point to aortic valve area. cpv: counts per voxel. (B) Quantification of RP805 uptake in CAVD on in vivo SPECT images. n = 8 in each group. (C) Examples of ex vivo RP805 planar images of the heart and aorta in control (left) and doxycycline-treated apoE^−/− mice on high fat diet (right). Arrows point to aortic valve area. cpp: counts per pixel. Three point sources are seen in the field of view. (D) Quantification of RP805 uptake in aortic valve area on ex vivo planar images. n = 8 in each group.