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. 2016 Aug;11(8):1204–1207. doi: 10.4103/1673-5374.189162

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Model of the effect of estrogens on cognitive performance improvement.

Molecular, cellular and tissue hypotheses integration for multilevel mechanisms of action to be tested in clinical trials. Physiological and pharmacological relationships at different levels of complexity lead into neuroprotective effects that are clinically relevant. TRPV1 channel offers a novel pharmacological target that may modulate the actions of estrogens with significant implications on clinical efficacy. ER: Estrogen receptor; TRPV1: transient receptor potential cation channel, subfamily V, member 1.