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. 2016 Sep 2;107(9):1223–1232. doi: 10.1111/cas.13003

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© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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NLRR2 expression is induced by CDDP and retinoic acid (RA) and contributes to RA resistance in neuroblastoma cells. (a) SK‐N‐BE and SMS‐SAN cells were treated with CDDP (10 μM) for the indicated time periods. The expressions of NLRR2 mRNA were measured by quantitative PCR. NLRR2 expression was induced by CDDP. (b) SK‐N‐BE mock and NLRR2 bulk stable cells were treated with RA and cell survival was analyzed using a real‐time cell imaging system. NLRR2 bulk stable cells showed significant resistance to RA‐mediated cell growth inhibition.