Figure 2.
Antitumor effects of NZ‐1 injected into the thoracic cavity in an NCI‐H290/PDPN malignant pleural mesothelioma orthotopic xenograft model. SCID mice (n = 5) were injected into the thoracic cavity with 1.0 × 106 NCI‐H290/PDPN cells. NZ‐1 (100 μg) or rat IgG (rIgG; 100 μg) intrathoracic injection began on day 0, and continued twice a week for 2 weeks. Rat NK (CD161a+) cells (1.0 × 106 cells) or control normal saline intrathoracic injections continued weekly for 2 weeks. Three weeks after tumor cell inoculation, the mice were killed, and the weight of thoracic tumors (white arrows) and volume of pleural effusion were measured. **P < 0.01 (values represent mean ± SE).