Figure 3.

Antitumor effects of NZ‐1 i.p. injection in a malignant pleural mesothelioma orthotopic xenograft model. SCID mice (n = 5) were injected into the thoracic cavity with NCI‐H290/PDPN (a) or NCI‐H226 (b) (1.0 × 10⁶ cells). Intraperitoneal injection of NZ‐1 (100 μg) or rat IgG (rIgG; 100 μg) began on day 0, and continued twice a week for 3 weeks. Intrathoracic injection of rat CD161a⁺ cells (1.0 × 10⁶ cells) or control normal saline began on day 3, and continued weekly for 3 weeks. Three weeks (NCI‐H290/PDPN) or 9 weeks (NCI‐H226) after tumor cell inoculation, mice were killed. *P < 0.05, **P < 0.01 (values represent mean ± SE).