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. Author manuscript; available in PMC: 2016 Sep 13.
Published in final edited form as: Mol Cancer Res. 2016 Feb 5;14(4):363–373. doi: 10.1158/1541-7786.MCR-15-0399

Figure 4. Suppression of polymerase delta expression upon miR-155 over-expression is likely mediated by the FOXO3a transcription factor.

Figure 4

(A) Microarray analysis reveals differential gene expression changes upon miR-155 over-expression. (B) Western blot to analyze expression of FOXO3a and POLD1 in presence of miR-155 over-expression in AV16 cells. (C) siRNA knockdown of FOXO3a in AV16 cells and analysis of POLD1 expression by Western blot. (D) Schematic representation of miR-155 over-expression repressing FOXO3a expression and preventing FOXO3a from activating POLD expression, ultimately leading to an increase mutation frequency.