Table 1.
Clinical characteristics of patients on recurrent GB trials
| IDH | |||||
|---|---|---|---|---|---|
| covariate | levels | ALL | wildtype | mutated | p_value |
| Initial tumor grade | 2 | 13(13.3%) | 5(6.7%) | 7(41.2%) | <.0001 |
| 3 | 10(10.2%) | 5(6.7%) | 4(23.5%) | ||
| 4 | 75(76.5%) | 65(86.7%) | 6(35.3%) | ||
| Imaging response | 0 | 49(50%) | 37(49.3%) | 10(58.8%) | .4797 |
| 1 | 49(50%) | 38(50.7%) | 7(41.2%) | . | |
| Number of recurrences prior to trial | 1 | 61(62.2%) | 54(72%) | 5(29.4%) | .0039 |
| 2 | 25(25.5%) | 12(16%) | 9(52.9%) | ||
| 3 | 8(8.2%) | 6(8%) | 2(11.8%) | ||
| 4 | 4(4.1%) | 3(4%) | 1(5.9%) | ||
| Extent of prior GB resection | Gross total | 23(23.5%) | 12(16%) | 8(47.1%) | .0052 |
| Near total | 18(18.4%) | 12(16%) | 5(29.4%) | ||
| Subtotal | 10(10.2%) | 8(10.7%) | 0(0%) | ||
| Biopsy | 47(48%) | 43(57.3%) | 4(23.5%) | ||
| KPS at initial tumor diagnosis | Unknown | 3 | |||
| <=80 | 21(22.1%) | 19(25.7%) | 1(6.7%) | .2744 | |
| 90 | 32(33.7%) | 25(33.8%) | 6(40%) | ||
| 100 | 42(44.2%) | 30(40.5%) | 8(53.3%) | ||
| KPS at GB diagnosis | <=80 | 21(21.4%) | 17(22.7%) | 3(17.6%) | .9417 |
| 90 | 36(36.7%) | 27(36%) | 7(41.2%) | ||
| 100 | 41(41.8%) | 31(41.3%) | 7(41.2%) | ||
| KPS at recurrent GB trial | <=80 | 64(65.3%) | 49(65.3%) | 9(52.9%) | .4661 |
| 90 | 16(16.3%) | 13(17.3%) | 3(17.6%) | ||
| 100 | 18(18.4%) | 13(17.3%) | 5(29.4%) | ||
| PFS6 | No | 72(73.5) | 56(74.7) | 12(70.6%) | .7635 |
| Yes | 26(26.5%) | 19(25.3%) | 5(29.4) | ||