Table 3.

Logistic regression model of the association between retrospective rates of acute chest syndrome and pain and having obstruction versus normal lung function in children with sickle cell anemia

	Model 1*	Model 2†	Model 3‡	Model 4§
Retrospective ACS rate	1.91 (0.35–10.35), 0.45	2.27 (0.38–13.60), 0.37	2.75 (0.44–17.31), 0.28	1.11 (0.12–10.38), 0.93
Retrospective pain rate	0.62 (0.24–1.59), 0.32	0.59 (0.23–1.55), 0.29	0.54 (0.19–1.51), 0.24	0.85 (0.32–2.21), 0.73

Definition of abbreviations: ACS = acute chest syndrome; CI = confidence interval; OR = odds ratio.

Data presented as OR (95% CI), P value. No. with complete data = 23 versus 91 with normal lung function.

^*Unadjusted model.

^†Model adjusted for age and sex.

^‡Model adjusted for age, sex, and sickle cell disease factors (hemoglobin [g/dL], white blood cell count, and reticulocyte percentage).

^§Model adjusted for age, sex, and pulmonary factors of interest (has asthma, bronchodilator response > 12%, early life environmental tobacco smoke exposure, ln [IgE]).