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. 2016 Sep 13;6:32992. doi: 10.1038/srep32992

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Results from PDX experiment testing the efficacy of BKM120 and the combination of crizotinib/BKM120 in inhibiting the growth of tumors in nude mice. Female nude mice of age 5–8 weeks were implanted with low passage CTG-0234 human mesothelioma patient tumor. Oral gavage treatment with combination of crizotinib (25 mg/kg) and BKM120 (10 mg/kg) reduced PDX tumor growth significantly relative to vehicle control. The combined treatment was much more effective than BKM120 alone.