Table 1.
Description of Included Reviews by Sedative Agent
| Sedative agent | Publication Year of Reviews (Range) | No. of Reviews Included in Analysis | No. of Studies Included in Original Reviewa | No. of Studies Included in This Overviewa, b | No. of Sedations Included in Overviewa | AMSTAR Score (Maximum 11)a |
|---|---|---|---|---|---|---|
| Ketamine | 2005–2010 | 7 | 14 (12–99) | 14 (2–32) | 3,052 (2,604–8,238c) | 4 (2–7) |
| Midazolam | 2004–2011 | 4 | 57.5 (4–99) | 4.5 (4–13) | 1,857.5 (301–4,978) | 3.5 (2–7) |
| Nitrous oxide | 2005–2013 | 5 | 26 (12–99) | 9 (3–9) | 116 (58–8,220)d | 4 (1–7) |
| Propofol | 2004–2010 | 6 | 51.5 (8–99) | 4.5 (1–7) | 862 (89–50,472) | 3.5 (3–7) |
a
Data are reported as median (range).
b
Study involved children (1 month to 21 years) and indication for use of sedation was procedure‐related and was performed in the ED only.
c
Green reported different denominators for different outcomes; the highest denominator is reported here.
d
Does not include review by Pedersen as not all study sample sizes were reported.