Table 4.
Frequency of Cardiac‐related Events Reported in Included Reviews
| Reviews | Bradycardia | Hypotension Requiring Interventiona | Death |
|---|---|---|---|
| Ketamine | |||
| Deasy 20109 | — | — | — |
| Green 200911 | — | — | — |
| Howes 200415 | — | — | — |
| Mace 200417 | — | — | — |
| Migita 200612 | — | — | — |
| Mistry 200514 | — | — | — |
| NICE 201020 | — | — | — |
| Midazolam | |||
| Jameson 20117 | — | — | — |
| Leroy 201019 | — |
2/135 (1.5%) 3 studies |
— |
| Mace 200417 |
24/393 (6%) 1 study |
— | — |
| NICE 201020 | — | — | — |
| Nitrous Oxide | |||
| Leroy 201019 | — | — | — |
| Migita 200612 | — | — | — |
| NICE 201020 | — | — | — |
| Pedersen 201316 | — | — | — |
| Faddy 200513 | — | — | — |
| Propofol | |||
| Lamond 20108 | — |
25/465 (5.4%) 4 studies |
0 |
| Leroy 201019 | — |
0/52 (0.0%) 1 study |
0b
1 study |
| Mace 201017 |
24/393 (6.1%) 1 study |
— | — |
| Migita 200612 | — | — | — |
| NICE 201020 | — | — | — |
| Symington 200618 |
24/393 (6%) 1 study |
25/465 (5.4%) 4 studies |
— |
Data are reported as n/N (%) and number of studies reported.
a
Clinically significant hypotension only (i.e. hypotension requiring intervention).
b
Outcomes reported per 10,000 patients.